Its effect on transfusion-related side effects, however, was only very modest: post-transfusion fever decreased but serious nosocomial infections remained unchanged and the effect on mortality was borderline [ 8].
More recent retrospective studies also suggest no significant advantage of SP on transplant outcome except for a modest improvement in transfusion requirement and neutrophil engraftment (8– 12).
More recent retrospective studies also suggest no significant advantage of ST on transplant outcome except for a modest improvement in transfusion requirement and neutrophil engraftment.
Recently, in a retrospective study of 196 transfused trauma patients receiving selective digestive tract decontamination, Juffermans et al. found a modest association between transfusion of RBCs older than 14 days and occurrence of new infections in multivariate analysis (OR 1.04, 95% CI 1.01 to 1.07) [ 65].
The benefit to risk ratio of the treatment with erythropoietin (EPO) as a means of limiting the number of transfusions in very preterm infants during hospitalization, seems to be modest since the adoption of restrictive transfusion criteria and of policy limiting phlebotomy losses.
We observed variations in the Hb concentrations which trigger a decision to initiate transfusion, distributed over a numerically modest but clinically significant range of 7 to 11 g/dL.
As anemia often evolves during treatment, clinicians should anticipate a transfusion requirement in those with more modest anemia.
Among the four eligible studies 14, 46, 51, 54 reporting transfusion outcomes, all reported at least a small or modest 31, 60 increase in transfusion volume with high-chloride fluid administration.
In particular, FON has been reported to be more effective than LMWH (only demonstrated by decrease in phlebography-proven asymptomatic DVT) with modest, although statistically significant, increase in bleeding and need for transfusions (with no related increase in fatal hemorrhage, in critical organs, or need for reintervention).
In contrast, those born after 1980 had modest to low exposure to risk factors (16 %–17 % were exposed to PAT, blood transfusion, and blood donation; 1.6 % had diabetes; and none had frequent or regular injections).
