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Moreover, the modest toxicity of intronic 160R expressed at higher temperature correlated with increased DPR production, but not RNA foci.
Moreover, of the two different administration routes, the intraperitoneal injection show the modest toxicity in Bio-ZnONPs treated groups and highest toxicity in Bio-CuNPs treated groups.
Mitoxantrone is an anthracenedione drug with mechanisms of activity similar to anthracyclines and a modest toxicity profile.
This is surprising given the widespread perception by healthcare professionals that endocrine therapy has only modest toxicity.
This observation, along with the modest toxicity observed, suggests this regimen is well tolerated in the adjuvant setting.
In another study (Calabrese and Baldwin 2003b), we presented evidence that responses immediately below the estimated threshold (i.e., NOAEL) gave evidence of modest toxicity.
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Although SDPF-RT has been the standard treatment regimen with modest toxicities for esophageal cancer, a less toxic regimen is preferred for more advanced stage cT4 disease.
A vast number of N-heterocyclic organometallic compounds have been applied for the polymerization on account of their modest cost, low toxicity, and the large availability of transition metals in stable and variable oxidation states, which makes them versatile precursors for these reactions.
Thus, the drug of choice for OA should be the one that preserves modest anti-inflammatory properties yet has limited or very low toxicity.
While vorinostat has shown modest efficacy as a single agent, its therapeutic advantage lies in a combination strategy, given its mild toxicity profile and enhancement of chemotherapeutic efficacy.
Meanwhile, compound 7f showed the modest antioxidant activity (0.55 eq of Trolox), good protective effect against H2O2-induced PC12 cell injury, with low toxicity.
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