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The CC genotype is likely to be associated with modest susceptibility to both COPD and lung cancer (G2 in Figure 1 and Table 4).
Consequently, increased attention has been shifted to An. sinensis due to its wide distribution, high abundance and modest susceptibility to malaria parasites.
The prevailing polygenic model of breast cancer risk suggests that a moderate number of genes, each conferring a small amount of risk alone (relative risk 1.3 1.5), together would combine multiplicatively, resulting in modest susceptibility to breast cancer [ 7].
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We do not yet know whether improved understanding of intermediate risk and modest risk susceptibility genes will lead to similar medical utility.
Both Lamivudine and Emtricitabine select for the M184V resistance mutation, which confers high-level resistance to both drugs, a modest decrease in susceptibility to Didanosine and Abacavir, and improved susceptibility to Zidovudine, Stavudine and Tenofovir [ 38].
With agents of unknown, and perhaps only modest effects on susceptibility, an inoculum size of 1 is50 is optimal for providing maximum statistical power to detect significant alterations in susceptibility.
A previous study of year-round IPTi predicted a modest increase in susceptibility following the prophylactic period which was outweighed by the cumulative benefits [53].
EIF2AK4 mutant mice showed innate immune defect and modest increase in susceptibility to DNA viruses' mouse cytomegalovirus infection.
It is possible that this study lacks sufficient statistical power to detect its modest effect on susceptibility for cervical cancer.
In addition, pathways occupied by robustly-associated genes can highlight additional genes with more modest effects on susceptibility but which may provide better targets for biomarker and drug development (Penrod et al. 2011).
Based on the extensive evidence that common genetic variation with modest effects underlies susceptibility to common complex diseases [ 12] and on the impossibility of linkage analysis to detect such signals [ 13], association studies have constituted the main tool for improving our understanding of the genetic factors affecting ALI susceptibility and outcome.
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CEO of Professional Science Editing for Scientists @ prosciediting.com