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Modest suppression of calpain activity with calpain inhibitors restores cytoskeletal architecture and promotes formation of a functional neovasculature, thereby reducing underlying hypoxia.
Only some repair defective strains (i.e. rad50Δ, rad51Δ, rad52Δ, rad55Δ and xrs2Δ) demonstrated a modest suppression of BRCA1-induced lethality (Table S1).
Indeed, we observed that eye-specific expression of RNAi-ubqn led to a modest suppression of the AICDREP (Fig. 6F compared with 6E), and a reduction in AICD levels in vivo (Fig. 6H).
MDA-MB-231 cells alone (with or without the 16311 antagonist) caused modest suppression of collagen mRNA.
It has been demonstrated that high dose ibuprofen causes modest suppression of NFκB transcriptional activity in CF respiratory epithelial cells.
A modest suppression of stimulated cortisol in glucocorticoid-untreated RA patients is not associated with decreased cortisol bioavailability.
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Specifically, the authors use siRNA to knockdown of MLYCD without providing any assays to determine if the knockdown was effective other than showing a modest suppression in total mRNA content that results in a modest suppression in cell growth.
The number of plasmatocytes was less affected by JAK/STAT signaling in the muscles, except for a modest suppression by the Stat92E DN construct (Fig 6E).
Second, PKG may directly phosphorylate the cardiac KATP channel or some closely associated regulatory protein to render modest to moderate suppression of the channel function (Fig. 2).
Overexpression of PTK6 in parental MCF-10A cells using either a FLAG-tagged wild type PTK6 (F-PTK6) or myristylated, membrane targeted PTK6 (MF-PTK6), was sufficient for a modest, but significant, suppression of cell death upon detachment from matrix (Figure 3A).
Treatment with AITC resulted in a modest but significant suppression of tumor growth 2 weeks following drug exposure (** P < 0.01 vs vehicle control).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com