Because of the modest study size and possible unequal distribution of subjects amongst motor syndromes, the small number of participants in the BRP dominant subgroup may not be sufficiently powered to adequately address real differences in imaging utility from other motor subgroups.
The evidence-base reporting the effectiveness of CPOE to reduce prescribing errors is not compelling and is limited by modest study sample sizes and designs.
There was a modest negative correlation between study size and change in micturitions/day (r = -0.21).
The study size was modest however, and a larger trial powered for clinical outcomes is required to confirm these physiological changes and determine whether they translate into improved clinical outcomes.
Preliminary criteria have been published by the EORTC/RECIST group[ 53 ] and the National Cancer Institute[ 54 ], but the imaging protocols, measures of activity and definitions of response have varied and study size has been modest.
Although our study size was only modest, the lack of association with tumor characteristics related to survival suggests that these nine genes are not likely to be useful in predicting outcome or suggesting specific therapies.
The substantial number of participants pooled for analysis offers more statistical power than individual smaller studies with modest sample sizes.
Given the differences in which agent was implicated, variation in ranges of exposure studied, and modest effect sizes, the evidence linking PFOA or PFOS and birth weight remains ambiguous.
However, when many of the above variables are controlled for, studies with modest sample sizes (n = 5 to 17 cases) have clearly shown that glucose-stimulated insulin secretion (GSIS) is defective in islets from T2D donors, relative to non-diabetic donors [ 16- 18].
However the limitations of this study (namely the modest sample sizes, further power restrictions also derived from the case-control age bias in Phase II and the potential differences between northern and southern European populations), we believe these two regions are good candidates for CRC susceptibility loci.
