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In addition, the fact that Ra-223 therapy entails substantial costs and modest side effects, such as myelosuppression and digestive malfunction, indicates a potential need for selecting patients suitable for Ra-223 therapy.
Gordon, for example, notes that rapamycin has well-known and relatively modest side effects and has been tested in many children already, so she and the others running the current progeria clinical trial are "seriously considering" whether to start giving an oral derivative of rapamycin to the children.
The combination yielded a high response rate, with modest side effects.
In China, traditional Chinese herbs with modest side effects demonstrate potent efficacy to cholestasis [ 5- 7].
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The modest side-effects, ease of administration and reversibility make this approach to therapy very attractive.
However, benefits in terms of prolonged survival and symptom relief are modest, whereas side effects are common, even when carboplatin is chosen over cisplatin for its favourable toxicity profile (Azzoli et al, 2009; Goffin et al, 2010).
All together these results may explain the relatively modest neural/non-neuronal side effects of the RTX-mediated molecular neurosurgery that systemically can create "chemical knockout" with lack of major behavioral deviances.
Despite the recent approval of several new therapeutic agents for CRPC, their overall survival effects still remain modest and their side effects are often not suitable for the treatment of elderly patients.
According to Dr Steve Harris, Circassia's CEO, current treatments are suboptimal: "Efficacy is relatively modest, and the side effects are significant, because you are delivering the very thing people are allergic to," he said, referring to the injections.
Despite modest effectiveness and considerable side effects, psychotropic drugs are frequently prescribed for these neuropsychiatric symptoms.
The consequence of a false positive test (i.e. prophylactic treatment with low-dosis haloperidol in a non-delirious patient) is generally modest as very few side effects of a low dose of haloperidol can be expected.
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