Exact(1)
The enhancer regions we mapped likely range in function from essential to dispensible, which is reflected both in the modest sequence constraint and rapid evolution between species.
Similar(59)
We used the power of 11,257 whole-genome sequences and 16,384 heptamers (7-nt motifs) to build a map of sequence constraint for the human species.
Despite a modest sequence identity, the two TRFH domains have the same entirely α-helical architecture, resembling a twisted horseshoe.
It has been reported that the toxicity of AMPs can be reduced by modest sequence modifications (Kim et al. 2014).
First, all show enhanced sequence constraint.
In the following, the handling of lonely base pairs, implicit structure constraint and sequence constraint contributions are discussed.
The sequence constraint C seq can restrict certain sequence positions to specific nucleotides.
Modest sequence differences within and outside PARCEL domains reveal only limited divergence.
Cxs and Panxs show similar membrane topology but only modest sequence homology [ 1].
From the 51 learned models, we calculate each sequence constraint's occurrence and only consider significantly present sequence constraints as reliable.
A modest sequencing volume generated approximately 5.7 MB of sequence data.
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