Sentence examples for modest repression from inspiring English sources
Cotransfection of β-cateninΔN with AmphiVent2mut-luc (like AmphiVent2-luc, see above) resulted in a modest repression of the reporter gene suggesting an indirect type of regulation.
Between four and six hours, modest repression (∼2 fold) of both R-luc protein and mRNA levels becomes apparent (Fig. 2A).
After exposure to 4-nonylphenol, we observed a modest repression of CYP3A in zebrafish.
Furthermore, this decrease in ribosomal proteins may result in a modest repression of de novo protein synthesis, which would allow the bacteria to overcome heat shock stress and adapt to the higher temperature growth conditions.
After the treatment with DCs presenting OVA, wild-type mice showed a modest repression of tumor growth under the skin compared to the PBS-treated controls (Supplementary Fig S6A, red lines).
Similar results were also obtained in T47D cells, but we observed a more modest repression effect by E2, as well as weaker activation of CYP1A1 (see Additional file 1: Figure S1A).
We note that although overexpression of Maf1 confers modest Pol III repression, no growth defect is observed, suggesting that cells must cross a threshold of very low tRNA abundance before conferring a clear growth defect.
In addition to this modest global repression, using ribosomal profiling, we identify a subset ∼200 of mRNAs that show much larger (>threefold), gene-specific changes in their TE during mitosis.
Normalized RL expression analysis revealed a robust de-repression of RL by ATA and modest de-repression by suramin sodium salt.
Thus in summary, the mitotic translational program is dominated by a modest global translational repression, combined with potent repression of a subset of mRNAs, which acts on top of the global repression.
On the contrary, cotransfection of β-cateninΔN with AmphiVent2-luc resulted in a modest but significant repression of the reporter gene.
