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About a decade ago, the big talk in the utility business was about tossing off the yoke of public service commissions, getting away from steady but modest regulated returns and becoming independent or "merchant" power companies selling electricity to hungry grids that would pay steep prices.
We find that the investments of European incumbents have not been resoundingly successful: although market entrance may have been justified on long-term strategic grounds, in the immediate term, segments acquired through competitive auctions have yielded modest regulated returns.
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Despite its broad hypomethylating activity, decitabine regulated a modest number of genes suggesting that hypomethylation of specific loci in particular cellular contexts is required to affect transcription.
Our findings highlight the potential importance of mesoscale heterogeneity introduced by relatively modest topography in regulating abyssal foraminiferal diversity.
However, the efficacies of many of the current BAT-listed options are modest, difficult to regulate and in some cases they may even be counterproductive with respect to other objectives ie pollution swapping.
Remarkably, only two of the three PD-linked variants of α-synuclein were IL-1β inducers in primary glia, and contrary to expectations from previous studies performed using cell line cultures and other studies involving modified α-synuclein species, our results show that the A53T α-Syn variant has instead a very modest activity in regulating the innate immune response by primary glia and microglia.
Fraser [ 65] reported that capacitation is a comparatively slow event that requires several hours to complete and is mainly regulated by a modest rise in [Ca2+]i, whereas the acrosome reaction is an exocytosis process that occurs very rapidly (within a minute) and is triggered by a large influx of [Ca2+]i [ 65, 66].
Cav-1 is regulated by testosterone, but at relatively modest levels when compared with PSA.
The overlap of orthologous genes between SYW and SYG was modest, with only 46 orthologous genes being significantly regulated by high copper.
The role of gene amplification/deletion appears to more modest, although several potentially significant genes appear to be regulated by copy number aberrations.
Indeed, previous microarray studies in the kinetoplastids have revealed relatively modest numbers of genes whose transcript abundances are significantly regulated (reviewed in [ 21]).
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