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Also, the PV power neural network forecast has strong regression values on all day types whereas the PV power persistence forecast has modest regression values on clear sky and cloudy days.
The modest regression coefficients confirm that there may be other clinical or respondent characteristics that influence the decision to recommend consultation.
Interestingly, while a 6-day repeating low-dose schedule only induced a modest regression of PC3 tumors in vivo, we showed that daily-delivered CTX inhibited by up to 80% tumor growth.
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In our prior study, this dose and schedule of DC101 induced vessel normalization and modest tumor regression in U87 tumors [24].
However, the ability of the physiological variables that were assessed in the present study to collectively explained the interindividual variability in endurance time to CET was modest, our regression model explaining only 25% of the variability in endurance time.
Chronic treatment with AKTi-1/2 caused a dose-dependent inhibition of the growth of BT474 xenografts (Figure 4B); 100 mg/kg completely suppressed the growth of the tumor with modest tumor regression, whereas 50 mg/kg only delayed tumor growth (Figure 4B; P<0.005 for 50 versus 100 mg/kg, and 50 and 100 mg/kg versus control).
Maximum changes from baseline in tumor measurements are shown in Figure 3, indicating that most responses of stable disease were associated with modest tumor regression.
In support of the possibility of using raloxifene for the treatment of ER-negative breast cancer, a study published while this manuscript was in review showed that raloxifene given daily by oral route to mice inhibits xenografts of triple-negative MDA-MB-231 and MDA-MB-468 breast cancer cells and also induces modest tumor regression of MDA-MB-468 cell xenografts.
Furthermore, in humans, a recent study of treatment with intravenous apoAI-Milano induced modest but significant regression of coronary atherosclerosis after only 6 weeks [16].
In a subsequent study in patients with low HDL-C levels, modest coronary plaque regression was demonstrated on serial intravascular ultrasound, but changes with RVX-208 did not differ significantly from placebo (Nicholls et al, 2013).
The present analyses show that the R values were modest for the regression models; therefore, other potential explanatory factors, especially direct tissue markers [ 45], must be identified to construct an optimal explanatory model (Table 3).
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