Even so, they observe a quite modest reduction of disparities between countries, i.e. a lack of sigma convergence.
However, PLZF itself is not absolutely required for ILC development, despite a modest reduction of ILC2 cells in Zbtb16 −/− mice (PLZF gene) (Constantinides et al., 2014).
The modest reduction of ventilation duration obtained with a conservative fluid strategy for patients who do not have evidence of tissue hypoperfusion makes impossible to create a "gold standard" for management of the fluid status of every ARDS patient.
Despite the progress in the mechanistic understanding of the pathogenesis of BPD, the therapeutic options to prevent this disease are still limited and drug therapies are of low efficiency resulting in an only modest reduction of BPD incidence [7, 8].
A multiple choice of antihypertensive drugs is available; however, a high individual variability to the antihypertensive therapy is still responsible for a modest reduction of the CV risk and not satisfactory control of blood pressure levels.
A modest reduction of truncated target transcript and protein was seen in cells expressing the ribozyme monomer, while nearly complete ablation of target transcript and protein occurred in cells expressing the ribozyme multimer.
Interestingly, this modest reduction of Rot reduced expression of Protein A as much as 10 fold.
These pathways might account for the modest reduction of Gli1 transcription by cyclopamine that we observed.
Mutations at GLS1, GLS3, and GLS4 (pDUSP1m3, pDUSP1m4, pDUshowed showed a modest reduction of glucocorticoid response (Fig. 2B).
Treatment with CDDO resulted in a modest reduction of CLL/SBL B cells in spleen and blood.
Forced expression of N1IC represses β-catenin signaling by over 90% whereas N2IC overexpression leads only to a modest reduction of 30% (Fig. 6C).
