Sentence examples for modest prolongation from inspiring English sources

Although docetaxel is the standard of care for these patients and is associated with a modest prolongation of survival, there is an urgent need for novel treatment strategies for metastatic prostate cancer.

Conclusions This study confirmed a modest prolongation of QT interval with citalopram, and identified additional antidepressants with similar observed risk.

RCCTs have contributed to improved adjuvant therapy and to modest prolongation of survival in the advanced disease setting for many malignancies.

48 When tumors truly become castrate-resistant, patients are offered docetaxel-based cytotoxic chemotherapy, which results in significant palliation of symptoms but only a modest prolongation in survival.

A modest prolongation of time to next therapy but not of OS was observed (23); a general recommendation for PLD use as maintenance therapy cannot be given (24).

In spite of the efficacy of adjuvant carmustine/lomustine-based chemoradiotherapy (RT) in achieving modest prolongation of median survival, the survival benefit did not exceed a few months.

The results of AVADO and RIBBON-1 showed that the addition of bevacizumab resulted in a statistically significant, although modest (1.0 2.9 months), prolongation of PFS.

Furthermore, the addition of cetuximab, a monoclonal antibody, against the extracellular domain of EGFR to the vinorelbine/cisplatin doublet resulted in a statistically significant, but modest, survival prolongation (Pirker et al, 2009).

7-NI administration produced a modest QTc prolongation measured during vERP assessment protocols in the left ventricle only (74 ± 2 vs 67 ± 3 ms at baseline; P =.02, Tukey-Kramer).

In this pharmacovigilance study using health records from 38 397 patients treated with antidepressants, we identified statistically significant evidence of modest QT prolongation for some pharmacotherapies, namely methadone and the tricyclic antidepressant amitriptyline, as well as for citalopram and escitalopram.

Another aspect of our work is noteworthy: we measured very modest APD prolongation in both LQT2-hiPSCN996I and NKX2.5 eGFP/w hESCN996I CMs when compared to their wild-type counterparts, with values shorter than those reported in other LQT2 hiPSC models (Itzhaki et al, 2011; Matsa et al, 2011; Lahti et al, 2012), and did not observe any early-after depolarization in the mutated cells.