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The compounds exhibited modest potency on TF/VIIa with selectivity over Factor Xa and thrombin.
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One way to address the modest potency of many substrate phosphorylation site ligands is to develop bisubstrate ligands.
This may reflect either the modest potency of phalloidin as a cytotoxin and/or resistance of melanoma cells to actin cytoskeletal poisons.
In such a scenario, the modest potency of CMAL compared to its fraction S-CMAL may be related to the presence of some antagonistic interactions in CMAL.
Moreover, compound 26 showed a modest potency of 0.13 μM against the enzyme, displaying no toxicity against MRC-5 human lung cell line, providing a promising selectivity profile.
Although caution is required in the interpretation of experiments relying on the use of a small compound inhibitor of only modest potency (raising the possibility of off-target effects), our data also suggest that—similar to the situation with HIV Gag even partial inhibition of MSP processing may impact on invasion efficiency.
St. John's Wort, for instance, has been demonstrated to be an antidepressant of modest potency in randomized clinical trials and thus, in the E.B.M. worldview, there is nothing "alternative" about it.
In general, modest potency enhancements were observed.
Biological evaluation revealed the constrained analog to be a selective serotonin 2C agonist with modest potency.
These bicyclic systems block the NR SRC interaction with modest potency.
One of the antibodies did inhibit virus infection, albeit with modest potency.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com