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Already, a sampling of four adult patients with BRAF V600E-mutated pleomorphic xanthoastrocytomas treated with vemurafenib shows that the best documented response is a modest, partial response [ 9].
A phase II trial comparing placebo (n=40), low dose (4.5 mg kg−1 loading dose and 3 mg kg−1 day 7 and every 2 weeks afterward; n=37) and high dose (15 mg kg−1 loading dose, 10 mg kg−1 on day 7 and every 2 weeks afterward; n=39) showed modest partial response (10%) with the high-dose regimen.
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A phase II trial of sorafenib in 37 metastatic melanoma patients reported a modest activity, with only three partial response (8% Min et al, 2008).
In this group of patients, activity was modest (3.4% partial responses, 24% progression-free ≥6 months), and the patients had substantial toxicity.
The partial response rate (14%), although modest, is within the range of what can be expected from an active drug in this setting and is along the lines of the findings in a recent phase II study (Gurtler et al, 2005), comparing two dose schedules of trabectedin in pretreated breast cancer.
For example, complete response (CR), partial response (PR), minor response, and stable disease rates of 0%to8383% have been reported, with a median time to tumor progression (MTP) of 6 to 49 weeks and with only a modest correlation between the rates of response, stable disease, and MTP.
Here is a modest, partial attempt.
partial response.
The overall response rate is 73% (complete and partial response).
partial response continuous phase modulation.
Pylorus-preserving pancreaticoduodenectomy. Partial response.
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