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Only a modest overlap was evident between the genes identified in these two studies [only one-third of the HLOFs of (7) were also found by (2)], suggesting that many HLOFs are population-specific and that a wider variety may be discovered across diverse populations.
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Since ST2 cells derive from mouse bone marrow and can differentiate along several different lineages [7], [59], [60], [61], while 3T3-L1 cells are mouse fibroblast preadipocytes [6], it is perhaps not surprising that only a modest overlap is found between the SRA-dependent gene expression changes when these two cell lines are differentiated into adipocytes.
This modest overlap is likely due to the use of a different chemical cross-linker, as well as to the presence of additional subunits in our full native Middle module.
This modest overlap is probably due to the fact that the highly dynamic context of a developing embryo, in which many different tissue-specific enhancers and pathways might be active, differs from that of a tumor derived from one particular lineage.
In contrast to the early stage of SVCV infection, DEGs with modest overlaps were found and resulted in cell damage.
A modest degree of overlap was seen for some items.
Window overlap was 50%.
Interestingly however, when the occupancy of histone demethylases and their proposed transcription factor targeting molecules have been compared at the genome-scale, the overlap is often modest.
This overlap is reasonable, considering the different, modest-sized patient groups, and different experimental approaches.
Some overlap is coincidental.
The overlap is considerable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com