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During 24 hours, the number of EGFP-ir cells in the SCN showed a modest oscillation, declining to its nadir at ZT0 and escalating to its peak around ZT12 in both rostral and caudal halves of the SCN, with the latter showing greater oscillation amplitude (Figure 5. Effect of time: F 6,56) = 42.53, p<0.001; Effect of position: F 3,56) = 219.45, p<0.001; two-way ANOVA).
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The amplitude of the oscillations was quite modest, with the sole exception of PHYB2 that showed a 7-fold difference between through and peak transcript levels (Figure 4).
By contrast, unshocked organoids (Fig. 5C,D) that had been pulsed with growth factors at circadian times 36 and 48 hours showed modest phase delays in PER2 oscillations relative to controls, more so following the pulse at circadian time 48 hours.
Concerning the overall amplitude of oscillations, photoreceptor transcripts showed modest fold-changes, ranging from about 2× (PHYF) to 7× (PHYB2) (Figure 4), compared to other diurnally regulated and circadian genes like LHC4 and GI (see below).
If oscillations are persistent in the deterministic model, then drift is not required to maintain considerable oscillations and population size only has a modest impact.
In the ADHD group, the SII predicted response showed modest early ERS composed mostly of alpha and some beta oscillations followed by corresponding ERD and a small beta rebound ERS.
In cells injected with dynamitin protein to inactivate dynein/dynactin, chromosomes showed modest changes in movement, with the only significant change being a decrease in rapid movements and oscillation (Fig. 3e, Movie 2).
Strikingly, unshocked organoids displayed modest PER2 rhythms during the first 8 to 12 hours of recording then spontaneously developed robust PER2 oscillations out of phase with shocked controls (Fig. 3A).
"We have gross oscillation here".
Her letters reveal a taut oscillation.
Robert: Modest.
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