The modest local orientation and overall chain deformation however indicate that intramolecular hindrances to extension exist.
Modest off-axis orientation still results in directional benefit: speech intelligibility can increase for signals up to 30° off-axis when using directional microphones (Ricketts 2000; Henry & Ricketts 2003).
Modest shared his sexual orientation and became his literary collaborator, biographer and closest confidant.
In contrast, mutation of claudin-1 residues L50, C54 or C64 resulted in more modest changes to ECL1 orientation, leading to an interaction with alternative CD81 residues.
Thus, while loss of Sgol2 delays bi-orientation, the modest over-expression caused by mRNA microinjection accelerates this process.
And second: this form of orientation is much more modest than the expectation of being able to virtually derive "right actions" from futures studies (Section 2).
The persistent, modest over-representation of the exposed orientation observed after long-term GR is supported by recordings using the subspace reverse-correlation-mapping technique [42].
Despite these additional interactions, the increase in affinity of 11 for importin-α was modest, possibly due to the alternative orientation of the lysine backbone (∼160° flip) relative to the native TPX2 peptide.
Between 2011 and 2013, theater educator and activist Alan Bounville walked 6,000 miles across the United States with the modest goal "to end gender and sexual orientation discrimination".
In essence, scaffold proteins represent a subclass of hubs that, being characterized by a modest number of interacting partners, provide selective spatial orientation and temporal coordination to facilitate interactions among bound partners.
