However, as the PI3K pathway is subject to tight autoregulation, such inhibitors often have modest or transient effects (Gordon & Banerji, 2013).
CTL or NK cells deficient in VAMPs4, 7 or 8, Vti1b, or syntaxin7 reveal modest or transient reductions in granule release, suggesting they are involved somewhere in the secretory pathway [ 39 41].
It is perhaps not too surprising that therapies designed to modulate one or more of the downstream pathogenic pathways resulting from dystrophin deficiency confer only modest or transient benefits.
They have absent, small, or transient leaves.
Despite the successful introduction of potent anti-cancer therapeutics, most of these drugs lead to only modest tumor-shrinkage or transient responses, followed by re-growth of tumors.
On the basis of these intriguing dynamics, it is not surprising that multiple randomized clinical trials with autologous bone marrow cells in acute myocardial infarction yielded modest, transient, or no improvement in cardiac performance.
58 Furthermore, the results from a series of electroretinographic studies in humans receiving sildenafil are similarly reassuring, showing either no effect at all or modest, fully reversible, transient electroretinographic changes that do not translate into significant effects on visual performance.
But doctors couldn't identify what triggered the minor stroke, known as a TIA, or Transient Ischemic Attack.
In the context of type 1 diabetes, and especially in patients with chronic kidney disease (CKD) who have the greatest risk of adverse outcomes (7, 8), activation of these pathways may offset or overshadow any gains achieved from modest and transient blood pressure lowering.
Lesions of the lateral mammillary nucleus yield surprisingly modest and transient spatial impairments, at least when compared with complete mammillary body or mammillothalamic tract lesions (Vann & Aggleton, 2003, 2004; for review see Vann, 2010).
Stimulation of M3 mACh and B2 bradykinin receptors in SH-SY5Y cells causes concentration-dependent, modest (2 3-fold) increases in cyclic AMP levels which are either sustained (pEC50 MCh (at 5 min), 6.54 ± 0.09) or transient (pEC50 bradykinin (at 1 min), 8.12 3-fold).
