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Current developments are considered to be more modest or small scale and need to address more local issues due to the lack of support from higher levels.
Sample sizes vary, with the majority modest or small.
However, most of them are of modest or small size and they are not expected to include a substantial number of participants (5 to 10 patients each).
And common variants in susceptibility genes are also of importance for majority individuals, although exerting merely a modest or small effect sizes contributing to the genetic background of diseases[ 33].
Each region demonstrated a HLOD score of greater than 1 but not exceeding 2. The study showed that susceptibility to TGCT could not be accounted for by a single major gene or even two major genes (like for example BRCA1 or BRCA2 in breast cancer) and was more likely to be due to several genes with modest or small effects on risk (Crockford et al, 2006).
Thermo-responsive polymers show a sharp change in properties upon a small or modest change in temperature.
Similar(34)
So, even in this large meta-analysis, power was still modest to detect small ORs and we therefore cannot exclude smaller effect sizes of the tested variants, resulting in lack of reproducibility.
For both candidate and GWAS identified SNPs the risks conferred by any one gene variant are small to modest (OR = 1.2 1.5) and cannot be used to effectively determine risk.
Usually, information is fragmented across many small or modest-sized trials, with selective publication and reporting.
However, power remains high at over 80% to detect small-to-modest effect sizes.
Most studies had small-to-modest sample sizes and none were nationally representative.
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