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Although the power of our MC4R analysis was modest, odds ratios were close to one, providing no suggestion of an association of this SNP with endometrial cancer risk among non-Hispanic white women.
However, given the relatively modest odds ratios seen recently with common polymorphisms, it is very likely that rare variants confer a substantial risk or protection from disease.
The power to detect modest odds ratios, such as those demonstrated in recent genome-wide association studies in RA [ 68- 70], was therefore quite limited.
This study has not been replicated, however, and was associated with a relatively modest odds ratio, less than expected with homocysteine.
Surprisingly, the common variant c.1676A > G (Gln559Arg; rs152451) was significantly enriched in cases versus controls, although with only a modest odds ratio (1.24).
The few genes that were significantly associated with disease had modest odds ratios, and overall there was insufficient evidence of the clinical validity and utility of the commercially offered genomic profiles [ 10].
Similar(48)
Throughout the night, Yaeji played big house and fast remixes, but much of her own material is lean and modest, at odds with the collared-shirt crowd that danced along.
"If I was a person observing it I would be, like, when will she stop?" In person, Egan is slight, modest, at odds perhaps with the force of her prose, which is lit by a casual brilliance and so compacted as to be almost tangible.
Familial predisposition has a modest effect (odds ratio (OR) 1.3 1.76) to the risk of stroke in general [1].
Finally, for the mixed-group, there was a modest (Peto odds ratio 1.51) but statistically significant increase of adverse effects with nicergoline.
The per-allele effect sizes of all six loci were found to be modest, with odds ratios approximately ranging from 1.1 to 1.2.
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CEO of Professional Science Editing for Scientists @ prosciediting.com