Our goal is to facilitate small to medium-sized projects that are best served by modest numbers of sample submissions from individual users, and that are billed on a per-lane basis.
Using a modest number of samples, correct chromosomal locations were identified by genome-wide association for three positive control non-segregating traits.
The restriction on the number of genes we analyzed, given a modest number of samples, circumvents methodological problems associated with other large scale expression studies such as microarray analysis that often preclude proper statistical analysis due to a high false discovery rate and huge family-wise errors.
By applying supervised classification, we are able to use qPCR results in a modest number of samples to impute copy numbers into a larger sample for which SNP array signals are available.
This is a consequence of the difficulties in adequately stratifying home microenvironments with the modest number of samples collected, combined with the home-to-home variation in home concentrations.
The signature definition and analysis algorithm presented here is not particularly computationally intensive as long as the analysis is restricted to a modest number of samples (i.e., up to a few hundreds profiles).
Clinical relevance of the subgroups was investigated by comparing the survival estimators; however, the combination of modest number of samples in some cancers (especially KIRC, READ, and UCEC) and very short follow-up times for many patients hindered the strength of this analysis.
Though the cell microarrays have slowly evolved to become a more widely accepted screening technology, in many publications, the individual arrays have contained only a modest number of samples, and data from multiple small arrays have been combined for large-scale coverage due to technological limitations of the methods [ 16, 20, 21].
Given the ease of sperm extraction from male birds in breeding condition, and a modest number of sampled males required for a robust estimate, this new index holds a great potential for mapping the risk of sperm competition across a wide range of passerine birds.
However, research to date has mainly adopted a literature-based miRNA-candidate methodology drawing conclusions from modest numbers of patient-derived samples.
