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Using a modest number of samples, correct chromosomal locations were identified by genome-wide association for three positive control non-segregating traits.
The restriction on the number of genes we analyzed, given a modest number of samples, circumvents methodological problems associated with other large scale expression studies such as microarray analysis that often preclude proper statistical analysis due to a high false discovery rate and huge family-wise errors.
By applying supervised classification, we are able to use qPCR results in a modest number of samples to impute copy numbers into a larger sample for which SNP array signals are available.
This is a consequence of the difficulties in adequately stratifying home microenvironments with the modest number of samples collected, combined with the home-to-home variation in home concentrations.
The signature definition and analysis algorithm presented here is not particularly computationally intensive as long as the analysis is restricted to a modest number of samples (i.e., up to a few hundreds profiles).
Clinical relevance of the subgroups was investigated by comparing the survival estimators; however, the combination of modest number of samples in some cancers (especially KIRC, READ, and UCEC) and very short follow-up times for many patients hindered the strength of this analysis.
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Given the ease of sperm extraction from male birds in breeding condition, and a modest number of sampled males required for a robust estimate, this new index holds a great potential for mapping the risk of sperm competition across a wide range of passerine birds.
A main reason for this is the difficulty in collecting even modest numbers of samples from subjects with pre-malignant oral lesions, as most clinicians see these subjects sporadically and lack coordinated infrastructure for sample collection and analysis.
Only a small number of samples have reached the W.H.O.
When a small number of samples per trial is combined with a high model order, then this means that the number of data points per trial is only a modest multiple of the number of estimated parameters.
While this study used a relatively modest number of patient samples (n = 78), the efficacy of the prognostic signature was validated in a larger (n = 295), partially overlapping set of clinical samples [ 16].
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Justyna Jupowicz-Kozak
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