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The candidate gene approach, which is restricted to an analysis of a few single-nucleotide polymorphisms (SNPs) in a modest number of cases and controls, has been supplanted by the unbiased approach of genome-wide association studies (GWAS), wherein a large number of tagger SNPs are typed in many individuals.
Over an average 11 years of follow-up, a modest number of cases were available (N = 574) for analyses of overall B-cell NHL risk.
This study demonstrates the effectiveness of using this SNP array for the finescale mapping of an inherited defect when testing only a modest number of cases and controls.
Similar power limitations to those described above apply to our analysis of these other mtDNA variants (and the nuclear variants), and these limitations are intensified in the screening phase where only a modest number of cases (n = 159) was considered.
Despite the relatively modest number of cases examined, this is the largest validation study using ECS as a clinical correlate.
Also overestimates may be a consequence of over-fitting a model with many risk factors based on only a modest number of cases and controls [ 28].
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Quartile analyses resulted in modest numbers of cases in some categories, limiting the power to detect associations if they exist, in particular for stratified analyses.
However, each study included a relatively small number of cases and therefore had only modest statistical power.
These studies have been further limited by a low number of cases (<600) reducing the power to detect modest associations.
This report is limited by the modest number of documented cases, drawing attention to the dearth of NS studies.
Diffuseness of the reported findings extended to histopathology; the authors reported four emerging histopathological variants of CTE despite the modest number of total cases.
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modest benefit of cases
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modest effect of cases
modest imbalance of cases
modest number of youngsters
modest number of jobs
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