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Compounds with more significant, yet still relatively modest modifications were then synthesised and tested by isothermal titration calorimetry (ITC) (Table 1).
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These modifications were considered as modest and unlikely to be clinically meaningful.
Some modifications were necessary.
Some lyrical modifications were made.
Even though the observed effects regarding histone modifications are modest (oscillating between 1.5-fold and 3-fold), this method in principle allows introduction of the mark not only at the desired locus, but also at a desired time [ 111].
Further modifications are almost inevitable.
First, not all loan modifications are equal.
Mortgage modifications are, in theory, appealing.
Modifications aren't cheap, though.
Despite the fact that users need to slightly modify their MapReduce program to use the iterative and incremental functionalities of iiHadoop, this modification is modest compared to re-implementing their algorithms on a different programming model, such as Naiad.
In general, effect modification was modest (Table 2), with the strongest associations observed for extreme heat.
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