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When cells are subjected to modest levels of stress (well below levels needed to induce apoptosis), their mitochondria fuse to each other forming a closed network, similar to networks observed when mitochondrial fission is blocked.
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Someone else may only experience small levels of stress.
Keep a low level of stress.
Further, when CAFs are grown on low stiffness gels (500 Pa, slightly above normal mouse mammary tissue stiffness) they do not form stress fibers or large focal adhesions and have only modest levels of nuclear YAP.
Through a detailed series of studies in which we examine the effects of expression of dSir2 at low, moderate and high levels on life span, we demonstrate that modest levels of dSir2 are indeed effective at extending life span, and that high levels of expression likely induce a cellular stress response that is reflected by induction of dnaJ-H.
Structural non-identifiability is seen to pervade even at modest levels of model complexity.
Anisotropic terms are often recovered satisfactorily at modest levels of theory.
Modest levels of anisotropy provide the most favorable conditions of self-organization.
We initially screened a small collection of these inhibitors and found modest levels of potency.
For all waning patterns, modest levels of vaccination of adults shortened SC.
Downtown Youngstown has seen modest levels of new construction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com