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An excitingly ambitious new play by Douglas Carter Beane, The Nance is held back only by some poor casting and a modest lack of context.
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In summary, the small-molecule p53 MDM2 binding inhibitors described in the literature so far have shown modest potency, lack of selectivity and inadequate pharmacological properties.
Although our study size was only modest, the lack of association with tumor characteristics related to survival suggests that these nine genes are not likely to be useful in predicting outcome or suggesting specific therapies.
In the movie, Ms. Zenovich traces the rise and fall -- and subsequent rise -- of Mr. Tapie, who became a successful businessman, singer, talk show host, yachtsman, soccer team chairman and politician despite his modest origins and lack of elite schooling (self-made men being virtually unheard-of in France).
When 2-AG or anandamide was microinjected, concentration-dependent elevations of [Ca2+]i were observed, and the Ca2+ response pattern was very fast, which is in contrast with the delayed, modest response and lack of effect, respectively, observed with the extracellular administration of these two agonists.
For most of these glycan modifications, the reported changes in FcγR binding are modest, however, the lack of core fucose results in much stronger, up to 50-fold increased, binding to human FcγRIII, due to glycan-glycan interactions between Asn297 in IgG1 and Asn162 in FcγRIIIa and FcγRIIIb (Shibata-Koyama et al, 2009a; Ferrara et al, 2011; Mizushima et al, 2011).
The Halls say they were staggered when LV= refused to pay their relatively modest claim, citing the lack of a burglar alarm.
She had never lived outside of Maine and she felt somewhat self-conscious in the social whirl of the nation's capital, given her modest origins and her lack of education.
Frankcom's intervention is, arguably, a bit over the top for a play that still shows its origins as a modest, studio drama whose lack of pretension was part of its charm.
Despite some suggestions from the Bush camp right after the election was decided that the proceedings would be kept modest, if only for lack of time to prepare, the scale of this week's activities is not much different from that of other inaugurations over the last two decades.
One modest example is the lack of substantial effort to retrofit or replace hundreds of schools in the state of Oregon that engineers have identified as likely or nearly certain to collapse when the next inevitable great earthquake is triggered along the region's Cascadia fault (there are struggles to prepare coastal communities for the inevitable tsunami, as well).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com