Sentence examples for modest inhibitory activity from inspiring English sources

The ribose derivatives (compound 9 and 10) exhibited modest inhibitory activity.

Series 1 demonstrated only modest inhibitory activity, but did reveal some important SAR findings including stereospecific binding.

The ester prodrugs (12a c, 14a c), which did not inhibit the COX-1 isozyme, exhibited modest inhibitory activity against the COX-2 isozyme.

The biological assay revealed that majority of compounds displayed modest inhibitory activity against thymidine phosphorylase at low micromolar concentrations (IC50 173.23 ± 3.04 to 14.40 ± 2.45 μM).

Though AG7088 is inactive (IC50 > 100 μM), the ketomethylene isosteres and tripeptide α,β-unsaturated esters containing both P1 and P2 phenylalanine residues show modest inhibitory activity (IC50 = 11 39 μM).

In this study, two biphenyl-linked 2-alkoxy-3-phosphorylpropanoate compounds (8 and 10) are found to exhibit modest inhibitory activity (IC50 ≈ 150 μM) against the TGase of Acinetobacter baumannii and good antibacterial activity against Staphylococcus aureus (MIC = 6.3 μM).

We found that some of these new derivatives exhibit modest inhibitory activities on the studied enzyme models, but it could be improved after structure optimization.

Compound 1 was found to effectively inhibit all three DHPS enzymes at 250 μM (BaDHPS, 86%; YpDHPS, 61%; SaDHPS, 46%), whereas binders 2– 10 displayed only modest inhibitory activities.

This series exhibited only modest NFκB inhibitory activity (data not shown) but showed significant inhibition of CK1 family members in a selectivity screen comprising 442 eukaryotic protein kinases.

All the synthesized compounds exhibited a poor or modest tubulin polymerization inhibitory activity suggesting another mode of action for these compounds.

These data suggest that modest class-I inhibitory activity of ACY1215, rather than its class-IIb HDAC inhibitory activity, is mediating the enhanced cytotoxicity of this combination therapy.