Immunohistochemical characterization showed that the in vivo MPEG-b- PCL-ran-PfLA) diblock copolyMPEG-b- PCL-ran-PfLAly a MPEG-b- PCL-ran-PfLAresponse.
This contrasted with a modest inflammatory response seen in the NMA regimen in which intestinal damage was limited.
The close relationship between intestinal damage and inflammation was further underscored by the fact that NMA resulted in only a modest inflammatory response with a completely different time course, and the virtual absence of severe intestinal damage.
Interestingly, neomycin, a potent ototoxic aminoglycoside antibiotic known to ablate hair cells in zebrafish neuromasts [ 17], generated a significant but modest inflammatory response.
In fact, an inflammatory molecular response expressed by local cells is crucial for tissue healing; PRP can reproduce this modest inflammatory response driving tendon cells to produce IL-6 and IL-8.
Analysis of lung responses in mice after subacute exposures to these aggregates showed a significant but modest inflammatory response among animals necropsied at week 0, 1, or 2 after the last exposure with recovery at week 3 post-exposure.
The increase in leucocytes are suggestive for a modest inflammatory response and in agreement with a number of studies showing comparable small increases in leukocyte numbers compared to baseline after dietary challenge [ 12, 14, 26- 29].
Unexpectedly, different from a local and modest inflammatory response caused by IKK- β induced NF- κB activation in hepatocytes [ 142], inactivation due to IKK- β deficiency in myeloid cells favors global insulin sensitivity [ 143].
Of note, saline-treated mice showed a modest increase in this enzyme, suggesting that the instillation procedure can induce a minor inflammatory response within the lungs.
f L, light inflammatory response; M, mild inflammatory response; S, severe inflammatory response; -, no inflammatory response; ND, not determined.
