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Probucol's beneficial effects on the renal and metabolic manifestations of Pdss2 disease occur despite modest induction of oxidant stress and appear independent of its hypolipidemic effects.
Wnt5a alone showed only a modest induction of both genes in keratinocytes.
In the presence of blocking antibodies, a few cells were detected that showed a modest induction of INFB1 or of DDX58 greater than the levels measured in control cells.
The induction of CISH and RHOH and the repression of IFNGR1 in monocytes after IFNγ exposure were confirmed by quantitative RT-PCR, as was the modest induction of STAT5A (Figure S2).
Previous work showed modest induction of MBF-dependent transcripts 60 minutes after irradiation with 500 grays, suggesting that MBF may be regulated by chronic activation of the G2 DNA checkpoint [19].
Our findings contrast somewhat with those of Ryoo et al. [22] who saw only modest induction of the Xbp1-EGFP reporter in the retinas of flies expressing the FTDP-17 associated mutant tauR406W.
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A modest induction (1.2-fold to 2.6-fold) of COX-2 mRNA by 5-aza was observed in a dose-dependent manner (Fig. 3a).
Firstly, in strain J447, none of the fusions displayed even the modest induction in response to DMSP.
We found that CDKN1C can be strongly induced by a combination of DZNep and TSA treatment compared to a modest induction by Aza (see below).
RA caused the greatest accumulation of RIP140 mRNA while estradiol and rosiglitazone caused a more modest induction (Figure 7B).
A similar, although more modest, induction was observed 6 h after phencyclidine (15 mg/kg) administration, but not after high doses of memantine and ketamine.
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