Sentence examples for modest genetic effect from inspiring English sources

These challenges include: (1) the large number of statistical tests; (2) complex phenotypes that are difficult to quantify; and (3) modest genetic effect sizes.

Unless otherwise specified, the value of h2 was set to 0.5% to simulate a modest genetic effect.

10 13– 15 Consequently, it was hypothesised that these European studies were underpowered to detect a true but modest genetic effect.

Overall, the single-point analyses of variations in the PADI1, PADI2, PADI3, PADI4 and PADI6 genes revealed a modest genetic effect size in the RA population and showed that the peak association varies between different ethnic groups.

For example, in order to achieve a power >80% to identify a modest genetic effect (odds ratio 1.2) of a polymorphism present in 10% of individuals, a sample size of 10,000 subjects or more would be needed [ 23].

Interestingly, the fusion protein, Abatacept (Orencia), a biologic drug with proven efficacy in RA, is a CTLA-4 analogue, highlighting the fact that relatively modest genetic effects may identify targets for treatment which are highly effective in large numbers of patients (18).

Modest genetic effects on morning, but not late-day, cortisol levels have been established.

Although most loci independently have modest genetic effects, they identify important biological pathways potentially relevant to disease pathogenesis and therapeutic intervention.

However, the modest genetic effects on ticagrelor plasma levels did not translate into any detectable effect on efficacy or safety during ticagrelor treatment.

The large size of this study (cases = 6,912/controls = 8,891) enabled us to detect modest genetic effects, explore gene-environment interactions, and examine potentially important subclasses of tumors, such as those defined by stage or hormone receptor status.

It may be difficult to see modest genetic effects of evolutionary significance and when identified may correspond to the particulars of a given year rather than the standard local conditions.