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The modest genetic burden suggests a substantial role for epigenetic or environmental factors in SSc susceptibility.
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Second, drug-drug and gene-environment (lifestyle) interactions may override the genetic determinants of medication response: for example, in the DPP an intensive lifestyle intervention benefits all participants regardless of genetic burden [ 70], and it is possible that higher pharmacological doses may simply overcome the modest resistance induced by genetics.
How does nature squeeze so many kinds of creatures out of such a modest genetic endowment?
This suggests a substantial difference in the genetic architecture of the two diseases with a heavier genetic burden for PsA.
Dr. Goldstein argues that the genetic burden of common diseases must be mostly carried by large numbers of rare variants.
Modest genetic effects on morning, but not late-day, cortisol levels have been established.
Despite that modest genetic contribution, mitochondrial DNA with mutant genes can cause serious and sometimes fatal diseases.
However, given the estimated greater genetic burden for PsA, we hypothesize that PsA-specific risk loci exist.
The children of those rapes, who are now becoming adults, who have born their genetic burden like a disgrace.
Despite this modest genetic divergence, they vary in many remarkable behavioral and morphological aspects.
The genetic burden of the human genome is enormous.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com