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SNP rs11872992 had a modest functional effect in vitro.
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By contrast, mAbs that do not block ligand binding have only modest functional effects [ 8, 9].
In contrast, anti-CD22 mAbs that do not block ligand binding have only modest functional effects [ 15].
These results do not disprove a functional effect of the substitution as it may be that the effect is modest or only apparent in vivo.
Current therapy most often focuses on pain relief, using mainly analgesics and nonsteroidal anti-inflammatory medications that have only a modest functional benefit and do not slow disease progression, whilst causing serious cardiovascular and gastrointestinal side effects [ 25, 26].
Instead there were studies, sitting rooms, drawing rooms and retreats -- modest, functional rooms for a year that called for modest statements and scaled-back ambitions.
Obese older adults with even modest functional limitations are at a disadvantage for maintaining their independence into late life.
The predicted functional effects of the splicing changes were consistent with our previous conclusions [ 15] supporting the thesis that natural variation in splicing patterns is likely to have only modest direct effect on the encoded protein sequences.
Our results support the previous conclusions of a modest protective effect associated with presence of at least one functional copy of GSTM1 gene; the prevalence of GSTM1 deficiency in LCs (54%) did not differ from that observed in HDs (54%), but showed a significant increase when compared with EDs (45%) (OR=1.46, 95% CI=1.00 2.12).
A modest antimigraine effect has been demonstrated for metoclopramide administered intramuscularly or intravenously [86].
Yet, VIP only showed a modest (10%) effect on histamine release in rat dura mater [52].
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Justyna Jupowicz-Kozak
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