Sentence examples for modest fold change from inspiring English sources

As we initially identified an over-representation of ribosomal genes and these tend to be highly expressed, which reduces the dynamic range of their fold changes, we used a relatively modest fold change criteria (1.3) in combination to our statistical threshold (q<0.1).

However, for this latter group of genes with modest fold change values, the microarray and qPCR data were always within four fold of each other.

A previous study by our group described reduced transcriptional heterogeneity between hESC lines (H1, H9, and RH1) cultured in physiological normoxia which was accompanied by significant upregulation, but with modest fold change differences, of specific integrin subunits (α6, αE, αV, and β5) in comparison to hyperoxia (21% O2) [ 31].

Jarid1c, also shown to escape X inactivation in the mouse [ 8], presented a modest fold change in all tissues, reaching significance in liver by microarray (FC = 1.12; P < 0.01) and qPCR (FC = 1.53 ± 0.06; P < 0.05), and in muscle only by qPCR (1.43 ± 0.01; P < 0.05).

Therefore, experiments to study the biological relevance of these modest fold changes are important to evaluate the significance of these changes.

The majority of altered sites showed modest fold changes.

19 Genes related to apoptosis were affected by FOS with only modest fold changes.

Thus, the modest fold changes could be one explanation for the relatively poor validation rate, which we have estimated at 60% (nine replicated fold changes out of 15 comparisons).

Comparison of miRNA expression between the two normoglycaemic strains (BN vs WKY) in the present study showed significant differences in the expression levels of 30 out of 152 (∼20%) detected miRNAs, with modest fold changes.

However, the results obtained by microarray and qPCR were not fully concordant, illustrating the difficulty in ascertaining modest fold changes, such as those expected for genes escaping X inactivation.

The observed modest fold changes in part reflect the use of primary cells in a short-term mammosphere assay, which is necessary to obviate any changes associated with prolonged culture of epithelial cells, resulting in smaller amounts of material post-culture relative to that obtained from the use of established cell lines.