In contrast, only modest clusterin expression was observed in non-tumorous pituitary glands and in GH/PRL- secreting tumors, while clusterin was undetectable in 76% of the very rarely encountered pituitary carcinomas.
Modest SERCA2 expression was detected in normal cervix tissues (n=9) and cancer adjacent normal cervix tissue (NAT, n=14).
Modest RNF11 expression was seen in 63% of the head and neck tumours, and 57% of the lung tumours, whereas renal and prostate carcinomas stained only weakly positive for RNF11 protein (∼10%).
The modest increase in MYB28 expression is, however, sufficient to result in an increased accumulation of glucosinolates in the 35S MYB28 lines (Tables 1 and 3).
A modest increase in Oct4 expression is known to induce a differentiation program in ES cells [ 7].
Our study shows that whereas SPG20/ Spg20 expression is modest and virtually ubiquitous in the adult and developing brain, early stages of embryonic development show maximal levels of Spg20 in the limbs, face, and forebrain primordia.
Myc is also unusual in that it binds and influences expression of an extremely large number of genes, however most often the influence on expression is surprisingly modest in the range of two-fold [2], [4] [9].
Apparently, a rather modest increase of E2F1, whose expression is under NF-Y control, is believed to drive the process.
This modest reduction in miR-9-2 expressisnots not expected to cause any phenotypic abnormalities, as none are reported in mice lacking this miRNA (Shibata et al. 2011).
Still, the clinical impact of the combined expression is rather modest compared with EMMPRIN expression alone, with a sensitivity of 93% and a specificity of 21% for expression of at least one biomarker, and 40% and 14%, respectively, for expression of both proteins.
