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2, 54, 55 Some notable successes have been reported from areas of modest endemicity 42– 45 where theory suggests that anti-parasitic drugs may have their greatest impact.
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Three of the six trials were conducted in low endemicity areas where transmission is low and thus any protective effect is likely to be modest.
However, three of the six included trials were conducted in low endemicity areas where malaria transmission is low and thus any protective effect is likely to be modest.
However, one needs to take into consideration that the majority of trials were conducted in low endemicity areas, where any effect is likely to be modest.
Sensitive diagnostic procedures to ensure adequate surveillance in areas attaining low endemicity are required.
The medians of EM- and EmA9-ELISA OD values of field faeces in high endemicity area were significantly higher than in low endemicity area (P<0.001 for both ELISA).
Brazil was categorized as a region of low endemicity.
No studies from settings with low endemicity reported malaria incidence.
In these low endemicity countries, outbreaks are common [ 64, 65].
In northern Germany areas of high endemicity appear to be interspersed focally in low endemicity regions [ 34, 35].
Three trials were done in low malaria endemicity areas and the other three in high endemicity areas.
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