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Whether there are subclinical effects of even modest elevations of maternal IAP on the fetus is completely unknown.
The risk alleles, T at rs12979860, or G at rs12980275 and rs8099917, were found to be significantly associated with modest elevations of baseline IP-10 levels.
To determine whether modest elevations of fasting serum glucose (FSG) and resting blood pressure (BP) in healthy adults are associated with differential serum vitamin D concentrations.
In addition, modest elevations of liver enzymes were noted with ALAT of 57 U/L as well as normal tests of renal function.
Modest elevations of plasma UCB in newborns and adults are considered beneficial owing to the antioxidant properties of bilirubin (Doré and Snyder, 1999; Doré et al., 1999).
In later studies of mouse islets with luciferase-expressing α-cells, there were modest elevations of ATP in response to 15 20 mM glucose (11, 14) concentrations, much higher than the 7 8 mM that maximally inhibits secretion (20, 24).
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The induction mechanism of LTP involves modest elevation of postsynaptic Ca2+ to activate protein phosphatases [10], in combination with NO acting in a cGMP-independent manner [11].
More modest elevation of ROS activates "redoxin signaling" which uses cysteine residues as redox sensors to mediate inflammatory responses [1], [5].
In the vast majority of cases, neonatal jaundice represents a benign phenomenon and the modest elevation of plasma UCB may exert neuroprotective effects owing to its antioxidant properties [3].
A longer exposure of the gel revealed detectable expression of the full-length Darpp-32 protein and perhaps a modest elevation of this protein in BT/HerR cells, relative to BT474 cells (Fig. 1B), but t-Darpp was clearly the predominant variant overexpressed in BT/HerR cells.
Of particular interest is the significant (p<0.05) but modest elevation of AEA in subjects with the FAAH 385 mutant A alleles (Figure 1), since AEA activates the CB1 receptor and has the potential to stimulate appetite and feeding behavior as well as modulate several metabolic functions including fatty acid metabolism and contributes to diet-induced obesity [12], [16].
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