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Gilman, J. G., Mishima, N., Wen, X. J., Kutlar, F. & Huisman, T. H. Upstream promoter mutation associated with a modest elevation of fetal hemoglobin expression in human adults.
More modest elevation of ROS activates "redoxin signaling" which uses cysteine residues as redox sensors to mediate inflammatory responses [1], [5].
The induction mechanism of LTP involves modest elevation of postsynaptic Ca2+ to activate protein phosphatases [10], in combination with NO acting in a cGMP-independent manner [11].
In the vast majority of cases, neonatal jaundice represents a benign phenomenon and the modest elevation of plasma UCB may exert neuroprotective effects owing to its antioxidant properties [3].
A longer exposure of the gel revealed detectable expression of the full-length Darpp-32 protein and perhaps a modest elevation of this protein in BT/HerR cells, relative to BT474 cells (Fig. 1B), but t-Darpp was clearly the predominant variant overexpressed in BT/HerR cells.
When we expressed S303A, S307A or S303/307A HSF1 mutants in hsf1−/− MEFs we observed a modest elevation of Hsp70 expression under normal growth conditions (Figure 7A, B) consistent with the hypothesis that S303 phosphorylation modulates both homotrimerization as well as transactivation by HSF1.
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Whether there are subclinical effects of even modest elevations of maternal IAP on the fetus is completely unknown.
The risk alleles, T at rs12979860, or G at rs12980275 and rs8099917, were found to be significantly associated with modest elevations of baseline IP-10 levels.
In addition, modest elevations of liver enzymes were noted with ALAT of 57 U/L as well as normal tests of renal function.
Modest elevations of plasma UCB in newborns and adults are considered beneficial owing to the antioxidant properties of bilirubin (Doré and Snyder, 1999; Doré et al., 1999).
To determine whether modest elevations of fasting serum glucose (FSG) and resting blood pressure (BP) in healthy adults are associated with differential serum vitamin D concentrations.
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