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Dopaminergic mechanisms may be involved in the pathophysiology of posttraumatic stress disorder (PTSD), although the evidence for this is limited; serotonergic mechanisms are implicated largely by virtue of the modest efficacy of serotonergic drugs in the treatment of the disorder.
The Truvada trial in MSM, completed in November 2010, had a more modest efficacy of 44%.
However, the modest efficacy of these drugs and emerging problems with anti-VEGF treatment resistance welcome the development of alternative antiangiogenic therapies.
First, this finding could explain the modest efficacy of anti-VEGF therapies in breast cancer.
This trial showed a modest efficacy of afatinib in a heavily pretreated lung cancer population.
Three studies have also demonstrated the safety and modest efficacy of cyclosporine A in PsA [ 115– 115].
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The modest efficacies of this and other experimental CSP-based vaccines, led us to question the importance of immune responses against CSP in the induction and acquisition of sterile protection.
Dopamine dysregulation is strongly implicated in ADHD; in fact, α7 receptor agonists show modest efficacy for the treatment of ADHD (35).
However, each of these drugs has only modest efficacy for AD.
Only modest silencing was achieved, but this was ascribed to low efficacy of the selected anti-HBV expression cassette.
Meridia's safety woes and modest efficacy are part of a long history of disappointing efforts by the drug industry to cure the obesity epidemic and cash in on the estimated $59 billion that Americans spend annually fighting fat.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com