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We emphasise that the relatively modest effects we document is a major phenomenon to explore.

Because of its modest effects, we did not further pursue the characterization of PCB-153 effects.

Given the modest effects we observed upon circadian period, the FLC-dependent change in expression level might be very slight.

Because our study design lacked power to detect common variants associated with small or modest effects, we restricted our focus to low-frequency variants with potentially higher pathogenicity (Fig.  2).

We believe it is more likely that the relatively modest effects we observed result instead from the procedure we employed: Firstly, subjects in the present study were not asked to engage in any explicit emotional processing during fMRI scanning; second, affective reactions were provided upon seeing the videos for a second time, after fMRI scanning.

Much of this success is due to better understanding of common human genetic variation [ The International HapMap Consortium, 2007], improvements in the throughput and cost-efficiency of genome-wide genotyping platforms, and the availability of large, well characterized, population-based cohorts that provide sufficient power to detect the modest effects we expect for complex traits.

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Conclusions: While the bedspace posters had a modest effect, we are now enforcing the guidelines through the weekly medical and nursing teaching sessions, and also ensuring all requests for clinical reasons are agreed with the registrar or nurse in charge.

Despite its modest effect, we decided to include IL-11 in our differentiation medium, since it was previously reported to enhance both the expansion and maturation of MKs.

However, the very modest effects that we observed from the three experiments suggest that any contribution of these residues to a binding site is minor at most, because in our experience, mutation of key ligand contact points results in a dramatic loss of activity (de Mendonça et al., 2005; Vaidehi et al., 2006; Wise et al., 2007; Hall et al., 2009; Nedjai et al., 2011).

This approach may currently be financially infeasible with the large samples required to detect the modest genetic effects we expect for complex traits, particularly for rare variant associations.

The modest effect, which we observed in BRCA1 mutation carriers, approaching statistical significance, and the clear benefit of the order of 25 35% in BRCA2, is for the most part consistent with the literature.

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