Preliminary data in cell lines showed that downregulation of NOTCH1 in NOTCH1 mutant cell lines leads to a modest effect of cell cycle acceleration and anti- NOTCH1 agents are only effective in NOTCH1 wild type cell lines.
This negative finding may be attributed to small sample size, relatively short duration of treatment and the overall modest effect of DCS.
Aside from this modest effect of stratification, major species mass fractions in the swirling flame are also closely approximated by laminar flame results at the local equivalence ratio.
Since our observers were free to change their fixation, this is consistent with earlier reports of a relatively modest effect of the pedestal disparity under these conditions (Brenner & Van Damme, 1998).
Considered "clinically modest" effect of "questionable valve" [144] R, CCS, NB HV C, Ip, AC, Ip + AC Aspirin Urinary salicylate recovery was 96.3 ± 7.5% in control, 70.2 ± 12.1% Ip, 56.5 ± 12.5% AC, 72.7 ± 14.1%, Ip + AC.
"It's a carefully designed study that shows there's some modest effect of controlled respiration on motion sickness," says neuroscientist Carey Balaban of the otolaryngology department at the University of Pittsburgh in Pennsylvania.
The modest effect of these VSRs in ovaries suggests that they do not interfere with piRNA silencing in this tissue.
Altogether, our data suggested that there was a modest effect of the pIX-TK in the triple pIX-modified Ad since high MOI had to be used.
In contrast to the modest effect of transcriptional regulation, loss of the fork-stabilization phenotype is associated with a increased sensitivity of several orders of magnitude (Figure 3A).
The modest effect of read-through on activation of the downstream reporter in cell lines could be related to the use of the Neo gene for selection.
Cells were treated with an equivalent concentration of nickel ions as an additional negative control; there was only a very modest effect of exogenous nickel upon zinquin fluorescence.
