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This approach, highly effective in detecting genes of modest effect, is susceptible to "population stratification bias" arising from differences in the genetic background of cases and controls.
Dr. Kerlikowske says that one reason why starting mammograms younger has only a modest effect is that younger women are more likely to get type of cancer called estrogen-receptor negative that grows faster and is hard to pick up on mammograms.
The adverse events profile is acceptable (if there are no safety concerns, one might wish to continue to ensure that a modest effect is not missed).
Such a modest effect is unlikely to be observable in the radial diffusion assay, although, as our results demonstrate, it is detectable in the liquid broth assay.
The latter possibility of a modest effect is supported by the positive reporting with respect to satisfaction with the intervention and a tendency toward a dose response effect from participants who stayed in the group until the study period ended.
Given the ubiquitous nature of alcohol use among the people of the world who are infected with HIV, quantifying the impact of alcohol consumption on HIV disease progression has major implications on the AIDS epidemic if even only a modest effect is found.
Similar(54)
A more modest effect was found for lung cancer.
A similar but more modest effect was also observed in WI-38 cells at PDL 36 (Fig. 2D).
Patients above each criterion had a substantial observed improvement in PFS on the PCF20 arm, while only a modest effect was observed below the criterion.
This modest effect was partly explained by poor rates of uptake and adherence to the schemes and a lack of intervention relapse prevention strategies.
A significant but modest effect was also found for maternal age (slightly elevated for children of mothers aged under 25 or aged 35 and over).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com