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Worse, cholinesterase inhibitors have a relatively modest effect and don't work for all patients.
Given the modest effect and common side effects, the role for intrathecal adenosine as a sole agent for the treatment of neuropathic pain may be limited.
Yet the drugs available to treat people, of which the best known and most widely used is Tamiflu, appear to have only a modest effect and have only been tested on seasonal flu, according to a report by the Academy of Medical Sciences and the Wellcome Trust.
Because of the multi-factorial nature of complex traits, each individual genetic variant generally has only a modest effect, and the interaction of genetic variants with each other or with environmental factors can potentially be quite important in determining the observed phenotype.
Deep in the Mid-Session Review is a claim that the Bush tax cuts could eventually raise the level of GDP by 0.7%, a relatively modest effect, and one that itself depends on the tax cuts being financed by lower spending.Look carefully, and Mr Bush's own forecasts do not expect the revenue boom to last.
Our results identify a few loci, each of modest effect, and each of which appear to affect a distinct branch in the PPG pathway.
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Interventions to change health-related behaviours typically have modest effects and may be more effective if grounded in appropriate theory.
Non-HLA candidate gene studies were less fruitful because they were mostly underpowered to detect modest effects and were frequently designed to investigate one or two functional polymorphisms, meaning that gene coverage was poor.
The argument against that being that sure, modest rises have modest effects and you just wait and see what will happen with immodest rises: immodest effects.
They are most likely to be relevant for Internet-based and printed patient information, and for people at low risk considering interventions that have modest effects and relatively important down sides.
Compared with traditional QTL mapping strategy, GWAS brings on major advantages both in power to detect causal variants with modest effects and in defining narrower genomic regions harboring causal variants [20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com