These results were thus contradictory: by themselves, the inhibitors caused modest dose-dependent cell death, but when combined with PDT they dose-dependently reduced cell death.
Adverse events reported with intravenous L-arginine in these settings include modest dose-dependent effects on blood pressure, potassium and phosphate [15], [16] and a potential for effects on acid base status [14] and blood glucose [17], [18].
VBP15 produced more modest, dose-dependent effects on ACTH.
In HT1080/DR4 cells, verapamil showed only a modest dose-dependent chemosensitising effect while the other compounds had no effect.
Aspirin treatment was associated with a modest dose-dependent increase in the proportion of cells in the S phase, while NS-398 did not significantly alter cell cycle parameters with respect to control cells.
Treatment with INCB13739 resulted in a modest dose-dependent (Ptrend = 0.026) decrease in total cholesterol, reaching a maximum of −7 mg/dl (−3%) from baseline in the 200-mg group (Table 1).
The postulated decision-making process around referrals can directly be invoked to make sense of the modest, dose-dependent, association between FD and previous home treatment: if previous home treatment reduces the uncertainty in the mind of clinicians about the likely suitability of a potential client, this may make treatment more likely to be offered.
Although lurasidone is reported to induce modest, dose-dependent PRL elevations [ 400, 401], especially at the beginning of treatment [ 402], as well as HPRL in some patients [ 71, 403, 404], in many patients it seems to be associated with no clinically meaningful PRL alterations [ 71, 405– 408].
The findings also indicate a modest dose-dependent increase in γH2AX foci following 24 hour incubation with Trichostatin A. Importantly, the results show a significant enhancement of doxorubicin-induced foci by Trichostatin A, particularly at 1 μM, highlighting a further mechanism by which the histone deacetylase inhibitor may augment doxorubicin-induced cardiotoxicity.
The effects of amylin analogs on lipid parameters appear to be modest and dose-dependent.
Upon screening select compounds against T. brucei BSF, 25 and 26 showed modest parasite dose-dependent toxicity with EC50 values equal to 34 and 17 μM, respectively, while 32, the most potent PFK inhibitor, did not show any significant parasite growth inhibition, for reasons that remain uncertain.
