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Phenotypic differences in liver metabolism also contributed to higher PCB 136 levels in the liver and feces from KO versus congenic WT mice, thus resulting in a modest distribution of PCB 136 away from other organs, such as the brain; however, the overall effect of the higher liver and feces levels was small and, at most, slightly decreased systemic PCB 136 levels in KO mice.
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However, owing to the potency of DTG, even modest distribution into the CNS may result in concentrations that provide antiviral activity.
"After the success of 'Nemo,' " he said, "Disney is likely to get just a modest distribution fee".
We observed several differences in racial composition and treatment patterns, and modest differences in distribution of tumor site.
Microglial reaction, as determined by Iba1 staining, in cerebral cortices was relatively modest and the distribution of microglial cells did not appear to follow the distribution of plaques.
So quite modest differences in the distribution of fitness effects, and effective population sizes can lead to substantial differences in the relative rates at which the 18S rDNA and protein coding sequences evolve.
Therefore, at best very coarse polar angle topography exists in these areas, with a tendency for some grouping of neurons that represent similar parts of the visual field, and/or a modest skew in the distribution of receptive fields across the cortical surface [4] [8].
However, at a population level modest shifts in the distribution of educational attainment could be important.
A previous simulation exercise of theoretical anti-tumor necrosis factor (anti-TNF) anti-body trials in sepsis demonstrated that modest differences in the distribution of unmeasured variables such as host genotype and pathogen characteristics could lead to trials in which the same drug produces opposing results, even when patients meet the same clinical criteria [ 14].
Instead, we used the macroscopic histological image of the tumor's cross-sectional surface a two-dimentional (2D) image (as demonstrated in Fig. 2a) with the assumption that there was modest macroscopic variation in the distribution of viable tumor tissues within a 1-mm thickness.
The primary difference appears to lie in the compounds involved in the clotting process; although modest discrepancies in the relative distribution of some compounds between these pools have also been reported [18] The clotting of blood maximally stimulates blood cell eicosanoid biosynthesis, and thus serum levels of these metabolites do not reflect physiological concentrations [19].
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Justyna Jupowicz-Kozak
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