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The early, modest differential effect of MVC on several markers suggests an additional direct effect of the drug on immune activation and inflammation.
It should be noted that this analysis also demonstrates an association between enhancers with c-Myc binding sites and other gene clusters with more modest differential expression [see Additional file 15: Figure S7].
Wang (10) examined the effect of this guideline change on hypertension control in diabetic patients during the time period 1995 through 2005 and demonstrated only a modest differential improvement in blood pressure control in diabetic subjects.
A possible explanation is that the Fe2+-Fur activated genes showed modest differential expression (approximately 2 fold) (Table 2), thus small experimental fluctuations could exclude some genes based on our cutoff criteria for differential expression in the microarray analyses.
Over the time course analyzed, GPAAT showed only a modest differential change in DGAT 17 relative to untransformed controls, whereas DGAT1 showed a strong differential expression change, as did PAP2.
With purified enzymes in vitro, this ratio was 25-fold higher for NfsA than for NfsB; taking into account a modest differential inhibition of the two enzymes by DMSO in the reaction buffer, the data indicated that NfsA is ∼18-fold more efficient at reducing CB1954.
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Increasing pressure for and new patterns of migration – globalisation has reduced income inequality between countries yet even modest wage differentials drive economic migration.
The modest socioeconomic differentials in influenza vaccine uptake were also unchanged over time (no significant interactions), i.e. the increased uptake was not at the expense of the less well-off groups but nor did it benefit them disproportionately.
This rather modest amount of differential exposure to competition, coming during the critical growth period, appears to have been sufficient to induce a different, long-lasting, behavioural phenotype.
Hence even a modest restoration of differentials could have a significant extra effect on wage bills.In this section Now, the snags Silver lining Granny farming Foxed Gordon Brown's progress Down on gowns Twitchy times for William Hague What's the differential?
It should also be noted that the presence in the current study of, for example, a modest but non-differential association (across regions) between financial hardship and lifetime suicidal ideation, tends to suggest that sub-regions with pervasive financial hardship (regardless of geographical location) will tend to experience higher rates of suicidality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com