For the cationic TEs, the generally lower pH in arable soils in Sweden may be one explanation for the modest deficiency problems observed despite rather low soil concentrations.
Even a modest deficiency in vitamin A is now known to exacerbate measles severity, and postmeasles bacterial pneumonias appear to be much more common in situations of poverty, crowding, and high bacterial circulation.
Interestingly, this effect of CARD9 deficiency appeared to be greater than the more modest effect of Syk deficiency, suggesting that other signaling pathways may remain able to activate CARD9 in the absence of Syk.
"He managed to manipulate these two women, who were both modest people, with serious deficiencies," Berna told me.
This association could only partly be explained by more prevalent secondary infections and an additional modest contribution of nutrient deficiencies.
Begin to remedy excesses or deficiencies with modest changes that can add up to positive, lifelong eating habits.
In the thalamus, cortex, and optic nerve, in contrast, the deficiency was modest or absent at 1 mo of age and reached 50% by 6 mo of age.
Next, we wondered whether, despite the modest effect of Atm-deficiency on tumor progression, lung adenomas in Atm-null mice had lost the senescence response characteristic of these tumors [37].
Even modest AT-III deficiency may lead to thrombosis [ 32].
Given the modest impact of Syk deficiency on SM1 T cells in vivo, it remained possible that some WT APCs transferred to chimeras during the T-cell adoptive transfer process were responsible for some of the T-cell response.
