Exact(2)
However, mutating all five sites of PQR to alanine resulted in only a modest defect in NHEJ.
Our finding of slight period lengthening relative to controls even at 18°C is consistent with a modest defect, with core clock effects getting stronger gradually as the temperature increases.
Similar(58)
In our hands, primary T cells deficient for either ezrin or moesin alone showed modest defects in T cell function.
Second, only modest defects were observed in fetal liver chimeras, demonstrating that the requirement for ezrin is independent of hematopoietic-lineage cells.
Given the moderate rescue of the anteroposterior patterning defects of grkΔFRT ovaries by the grkGLSmut transgene, we expected only modest defects in the transport and anterior localization of grkGLSmut transcripts.
The mutants in that complementary study showed modest defects in translation activity.
The other six mutants that displayed more modest defects in SER3 repression also had more modest reductions in the MNase protection across the SER3 promoter.
Furthermore, H775A and T776A mutations result in modest defects in Ub ligation to Sna3C, and an F778A mutation results in a more severe defect.
TRPV4 knockout mice also exhibited modest defects in heat-evoked pain sensation, though this phenotype was virtually absent in TRPV3/TRPV4 double knockout mice.
Overall, toeprint band intensity did not correlate well with translation activity, suggesting that something else regulates the modest defects that were identified in that study.
Curiously, mlh3 Δ mms4 Δ double mutants displayed spore viability levels that were greater than observed in mms4 Δ strains that show modest defects in crossing over.
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