At higher PPi concentrations, there was modest inhibition (data not shown); however, quantitative analysis of inhibition was not possible because of PPi solubility restrictions.
Interestingly, we observed that Taf9b KO mice display defects in eye development including microphthalmia and cataracts-like phenotypes albeit with modest penetrance (data not shown).
During the pharyngula period (24 48 hpf) and hatching stage (72 hpf), overlapping expression patterns between grna and grnb include the pharyngeal and anterior visceral endoderm, the skin epidermis, and the pronephric tubules, albeit at modest levels (data not shown).
Cleavage of PARP and lamin A was detected in cells treated with MIF, 4-OHT plus MIF, and 4-OHT plus U0126, but only at later time points and at modest levels (data not shown).
Among the patients who underwent serial DCE-CT on this study, no informative changes were observed in tumour blood volume, Ktrans, permeability surface, mean transit time, or blood flow, though interpretation of these results is limited by the small sample size and the modest therapeutic efficacy (data not shown).
In general, however, the effects of Nr2e3 and Neurod1 mutations on rod gene expression are modest [18]-[20] [18]-[20] not shown).
VIGS-induced silencing of single or double PhGID1 genes resulted in only modest dwarfing and a low silencing frequency (data not shown).
We found a borderline significant quadratic association for chronic liver disease, but graphing the results showed only a modest deviation from linearity (data not shown).
This series exhibited only modest NFκB inhibitory activity (data not shown) but showed significant inhibition of CK1 family members in a selectivity screen comprising 442 eukaryotic protein kinases.
Furthermore, triple mutants only showed a modest change in morphology (data not shown), unlike the single receptor mutants that demonstrated striking changes.
