Our results provide evidence for relatively modest genetic constraint to evolution, particularly as a result of genetic covariances between traits.
The enhancer regions we mapped likely range in function from essential to dispensible, which is reflected both in the modest sequence constraint and rapid evolution between species.
Then Matilda, it seems, would not act from a mechanism that was responsive to fairly modest rational constraints.
Our results indicate modest demand-side constraints on taxation and budgetary institutions.
Clooney's career has been more than a search for a still head, but his best performances, in these more modest movies, have involved constraint, one way or another.
We also noted that some (but not all) of the peaks in the dyad positioning analysis were shared with naked DNA (see Additional file 1, Figure S5a), indicating that in this range of apparent positioning scores, MNase biases may coexist with real (but modest) in vivo positional constraint.
These findings suggest that despite in-country financial constraints and modest CDC funding, targeted technical assistance, such as laboratory assessments with specific recommendations, can lead to substantial capacity building improvements.
During initial cancer trials, didemnin B exhibited modest activity and displayed the constraint for the treatment with anti-emetics [250].
Though only 2,600 units of the RAV4 EV will be produced, Mr. Berman expects the car's cult to grow well beyond the constraints of that modest number.
In most economies, these macro-prudential policies are modest, owing to policymakers' political constraints: households, real-estate developers, and elected officials protest loudly when the central bank or the regulatory authority in charge of financial stability tries to take away the punch bowl of liquidity.
