While disordered heterogeneity tends to dissipate convection through dispersive mixing, an ordered heterogeneity (e.g., sets of vertical fractures) allows instabilities to propagate at modest combinations of fracture aperture and separation distances.
Despite its modest efficacy, combination endocrine therapy offers an alternative option particularly in patients with heavily pretreated disease and limited bone marrow reserves and for patients with poor performance status who would not tolerate cytotoxic agents.
Numerous targeted small molecule inhibitors are being developed as a new approach to cancer therapy; however, as tumours often have defects in multiple signalling pathways single agent antitumour activity is modest thus combination treatment is being investigated.
According to our regression model, however, even though the ORs are modest, the combination of MTX and TNF blocker appears to protect against SSI, whereas MTX and possibly other DMARDs almost emerged as a risk factor in group B (Table 4).
Japan's new inflation target is relatively modest, but the combination of the higher inflation target, quantitative easing, and a substantial yen depreciation seems to be energising the Japanese economy.Isn't depreciation just a beggar-thy-neighbour measure, though?
Thus, although these results show a modest benefit from combination therapy, the dosages of psychotherapy needed for adolescent TRD should be further studied [ 12, 47].
However, this modest effect in combination with serious adverse events and/or the need for close monitoring, make therapeutic options such as immunotherapy [ 74], cyclosporine [ 92] and gold [ 98], problematic and inappropriate for clinical use.
In general, the antitumor efficacy of CDK inhibitor as monotherapy is modest, and rational combinations are being explored, including those involving other targeted agents.
While single agent HDACi treatment has only modest activity, drug combinations with chemotherapy have been studied, with some trials being positive [ 9], others being limited by toxicity of the combination [ 35].
For the RLC model, a "local" collapse equates to integrating out the location indicators δ k on branches near the affected portions of τ and reduces to a discrete summation over a modest number of combinations.
